Go the 210 east to the 15 south.
I live in victorville (next to adelanto) work in san pedro; during the week I stay in pedro!
I have traveled all of the freeway systems in los angeles, my birthplace and home for too many years, stay off of the 405, 605, 57 even if you are NOT towing, even at night!
I personally avoid 395 from 58 south as this is where many highway deaths occur. I did work in Lone Pine for 18 months so I know 395 well.
If you DO want to take 58 west to the 15 south, this is also a good route; there is 2 lanes in each direction most of the way east of 395. Tehachapi is a real nice place to layover, you will like that town, VERY SAFE, although snow is expected this weekend.
hope this helps you decide