Boy I wish I knew that before I ordered mine with the 3. 73's.

4:10's sound like the way to go... [/Q
me too. but mine still runs at 1700 at 70 with the 3. 73 4. 10 just 150 more rpms. will that little of a rpms diff make that big of a diff . if so i might consider changing out.
150 more RPM means some more horsepower. This means some more fuel.
YOUR rig at 70mph might need the higher HP figure. It might not.
What is your load weight/hill-grade/head-wind resistance, compared with driver "X"?
If he is appreciably heavier/climbing steeper/has more headwind than you, and the 4. 10 is perfect for his situation,... then that same 4. 10 in your rig, under YOUR conditions, would be wasting fuel. It would be the equivalent, for you, of driving around in a lower gear, running higher revs and generating more HP than is needed for the task of the moment.
If/when you find yourself in his circumstances, shifting down a gear will get your rpm's and HP up HIGHER than his, and you will have easier going than he will,... at the same speed, ... but will of course pay for that ease in the additional fuel burned to create the greater HP. (you will make up for this fuel "waste" by "saving" more with your higher gear during the easy portions of the run.
That "little of (additional) rpm's" will/will not be desirable, depending on the conditions.
Bottom line,... the 4. 10 guy, with the same transmission(and same tires), in the same gear,... will always be running in a lower OVERALL gear (trans. plus rear axle) than the 3. 73 guy.
Sometimes that is great,... sometimes it's not.
In almost every situation other than starting heavy from a dead stop,... you can get a lower-overall gear than the 4. 10 by shifting down the 3. 73 one-gear.
On the other hand, running light/or heavy-downhill, downwind,etc. ,... i. e. any time your truck is not forced to work hard,... you will have a better mpg potential in the highest gear with the 3. 73.
One size does NOT fit all (conditions).
Slowing down a bit will make more difference that anything discussed here.
Wind resistance goes up with the square of the speed,... and so do internal losses in the engine. (Each air molecule is hitting your truck with twice the force, since each molecule is hitting at twice the speed,... and because you are covering twice the distance in the same time-frame, you are hitting TWICE AS MANY of the DOUBLE-FORCE molecules!) 4 times the air resistance at 2 times the speed.
The additional HP to overcome these (and other) increased resistances comes from your fuel tank/budget.
If hurrying-up doesn't make you more money,... this is worth remembering.