I have been running MTRs since they started making them. I ran the unidirectional MTs before that on my '84 F-150. MTRs are awesome, except for the tread wear. I guess you could get 40k out of them if you run them to the bars, I usually get about 20k because I need traction real tread provides.
I suggest frequent rotation. I squared two by running them too long on the front. I would suggest rotating them every 10K. See the "square tires" tread for details.
Only guys who run swampers would consider this a quiet tire. My friend down the street says he can hear the tire noise before the engine noise on my Ram when I come to visit.
As for siping, I haven't tried it. If you are frequently driving in snow, it would be a consideration. I need the support of a full block due to the amount of time I spend on granite. I've seen granite pull entire chunks out of tires due to the sipe. The sipe weakens the block.
You can do things with these tires in two wheel drive others need 4x4 for, as long as you have modified your rear suspension to handle wheel hop :-laf
The biggest problem right now is with the strike at Goodyear, you can't find MTRs in 17" anywhere. If you do, let me know as I need two.
Merry Christmas