You build a Pickup around cost, HP wars, and an expected 100,000 mile lifetime or less before the new vehicle buyer dumps it for another new one. You care about the used market why again while making new wigits?
The Commercial Market is different from the weekend 5er towing and DD use. It's Tow trucks, box delivery trucks, utility/service with cranes, and other commercial vehicles on the road all day with expected 500,000 mile or better lifetimes while loaded to the max all the time. Creature comforts and horsepower take a back seat to fuel economy and ease of maintenance. Don't forget the engine running while the wheels are not turning uses. Carpet cleaning with PTO engine driven pumps/vacuums, crane operation, bucket operation, etc. that change oil by engine hours not miles.
You de-rate the engine so it lasts longer and burns less fuel. It = engine, transmission, driveline, and everything else that wears out faster with higher power levels like the oddball you wouldn't think of it cooling fan clutch. (The RAM Long Hauler also has a derated engine for longer life.) The 4500/5500 is expected to be at full load most of the time so extra power just wears things out faster. MPG is critical to profit in commercial trucks. Low by consumer vehicle standards MPG reflects the work the truck is *always* doing by hauling around 1-2 consumer vehicles. Commercial interest have put 55 MPH and other stupid traffic impeding speed limiters on their trucks for better MPG. HP wars and you blowing it's doors off with your 3500 are reasons to fire their driver for even trying to race you. So the HP wars do not apply to the commercial market unless maybe they are pushing an underpowered dog that costs them extra time without saving enough fuel to cover it. Running out of DOT hours of service because the truck is slow is a valid concern.
The original reason diesels were popular was not the stupid power they have today, but, cheap fuel and sky high MPG.
I will say it again cost and MPG are important in the 4500 and 5500 market. 1 MPG can be the difference between profit and loss. Yet you can't make things too light and have it breaking down all the time so MPG is traded for heavier parts that will last.
Think of the underpowered 6.2 Detroit Diesel GM used since 1982. They dropped an economizer ~100 HP 6.2/6.5 NA engine in Frito Lay delivery vans. The lowest rating for the engine otherwise was ~130 HP. Fun day at work trying to get that gutless wonder out of it's own way all day.
There is a difference in insurance and license plates on 2500's vs. 3500's in some states where the 3500's have to have commercial plates. So some of the 2500/3500/4500/5500 is just a game of the system.