6" could be a benefit, if...
I have a 5" that I fabbed up for my 2wd and it cleared the axle just fine. 5" looks awesome, just the right size IMO. Now 4" exhausts look a bit wimpy!
6" is overkill IMO, however, when I set my High Idle to 1500rpm and then go stand by the tailpipe, there is a ton of air rushing out at a considerable velocity, even from that huge pipe. From that you could almost surmise a 6" system COULD be beneficial on an extremely BOMBed B-series (given it has at least an HX40 or B1 turbo & head porting, etc. etc. in addition to massive fueling).
Vaughn