Its not that it wont work but with those tall tires your trans is going to work a lot harder. The truck is going to fell lazy. And you wont see 20mpg with that truck up in the air like that on tall tires, sorry. Dont believe 1/2 of what you read or told about mpg. My 2wd 93 got 24mpg twice it gets around 19. My 04. 5 got 21 2 or 3 times but it's average is 16. It is easy to remember those 72 degree, tail wind days. How you drive it makes a big difference. My guess is lifted+tall tires+mods=you cant keep your foot out of it. And "there's nothing wrong with that". I am thinking of putting 4. 10 in my 04 I wish they were there I tow big with it. If you are going to try it do just the rear axle, drive it for a weak or so tell us what you think. Take the front drive shaft out and leave it out until the gears match.
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93 250 2wd xc 354 auto 266k
04. 5 3500 4wd cc dully 373 6speed 90k