Not sure if this contributed to killing my VP44 or not, but the week before it died I turned the pressure up to 22 lbs. The next weekend I changed the OEM filter out, and it would not restart (VP dead). Up unitl that point it had been run at about 13psi for its 130k miles pretty much flawlwssly until then. . Im very leary about anything over 16-17 psi to the pump, but some others swear higher pressure is ok. So take your best shot from the info you have available is what I say. I know I have heard from 2 VP44 rebuilders, and the first one said stay under 20, unless your in competition, the other one said keep it at 13. 5 +/- 3 psi. (they both are racers and well known) .
I suspect that anytime you work on the fuel system your introducing air bubbles and/or spikes in pressure that arent good for the pump, and maybe thats why some poeple that dont maintain their truck and just drive it can go forever on theirs. .
After mine poofed out, I added an air bleeder valve at the VP so that now anytime i fiddle with it, can always run the air out the valve back to the tank for a few minutes before subjecting the pump to turbulant fuel. .
Time for someone to chime in and and say they've run 50psi for 300k miles and get 28mpg doing it. . hehe (while towing)