I just moved out of a 2005 C5500 with the 6. 6 DMax/Allison. It was a regular cab with a mechanic's tool body. Max GVW was 26K. With me and my tools, I was right around 22,500 all day long. Hauling big parts could easily put me right at max GVW. I had the truck for about 10 months. During that time I drove it from 50,000 to 74,000 miles. I didn't have any problems out of the engine at all, however I felt like it really de-rated during warmer weather. It started easily, wasn't too bad to service, only used 3/4 gallon of oil between changes, and was quiet. The transmission was annoying. It shifted great, but it never stopped shifting, ever. The cruise control was worthless on anything other than level ground. When I hit a hill on cruise, it would slow WAY down before the computer would tell the engine to fuel. After I crested the hill, the truck would continue to fuel for 6-9 MPH past the set speed before backing down. The brakes were OK during normal driving. Panic stops would leave me wishing for much more braking. The suspension was OK. I never expected it to ride very well... which is good because it didn't. The rear limited slip differential worked well, but all that traction was wasted because the rear axle would get severe wheel hop during low traction situations when wheel speed could have saved the day. The engine had a factory exhaust brake, but it really wasn't very strong. Also, the programming didn't really make the most of it. It was great slowing down after getting off the interstate, but it wouldn't even come on with the trans shifted to 1st or 2nd trying to keep from having to ride the brakes down a long downhill from a dead stop at the top of the hill.
The A/C worked very well, but I had to replace the compressor at 58K miles.
Probably the worst thing about the whole truck was the inside of the cab. I'm 6'1"/205lbs and I am way to big for this truck. There just wasn't enough leg or head room for a normal person like myself. The interior was CHEAP... and that's coming from a Dodge Ram owner. I had more self tapping screws that you could count keeping the interior panels from rattling. Also, as quiet as the engine was, at cruising speed the inside of the cab was really loud.
Bottom line is I really didn't like the truck, but it never let me down either. The interior, transmission, and wheel hop ****** me off nearly every day.
I've had the following roughly similar trucks to compare this one to:
1995 TopKick with CAT 3116 and Eaton 6spd. Slow, but best driving. Tough as nails. Great in the dirt. I had it from 410,000 to 440,000 miles.
2006 F550 with 6. 0 PSD and Torqshift auto. Engine spent a lot of time in the shop. Lots of turbo lag. Steering sucked. Hard to keep it on the road. Good in the dirt other than low ground clearance and hard to steer when on the throttle. Transmission is great. Variable geometry turbo in tow haul mode has good braking. Had it from 36 miles to 55,000 miles.
2005 C5500 with 6. 6 DMax/Allison. 55,000 to 74,000 miles. Good engine. Trans shifts too much. Exhaust brake doesn't live up to potential. Interior, CHEAP and cramped. Wheel hop in dirt. Bad.
2005 F750 with C7 CAT/Allison. 55,000 to present. Good engine. Louder, but great low end. Exhaust brake works great. Trans shifts well. Drives good. Lots of room in cab. Has great features like speed control/cruise control, air brakes stop GOOD, and air operated differential lock.