250k may or may not be the end of life for the that truck. dependes on the life it lived, and the maintance it recieved. i have rebuilt a few 6. 2/6. 5 engines that had well over 300k on them, and had the hatch marks still on the cylinders, and little to no wear on the bearings. biggest issues are the pmd's on the pumps, keep them cool and they will last a lot longer. next biggest issues is egt's. for a truck thats worked, and driven by a person who knows not how to drive one, egt's are the biggest killer's of these engines. generaly piston's develope cracks and the rings become brittle,resulting in blowby, and an engine that misses. next is valve pitting, here again egt's. last biggest issue is harmonic balancer's causing the cranks to fail. there are some other issues as well, but these are the most common and easiest to prevent. i own 3 different 6. 2/6. 5 trucks with over 250k on them and no major issues. to say they have been worked is an understatement!