My truck has not seen #2 in 3 months. Only thing to really watch is the fuel filter but since your truck is new there should be no problem. Bio will definitely clean the fuel system. My truck runs better on bio and sometimes sounds like a 12v, much smoother, feels like more pep and actually gained 1mpg. Bio has twice the lubrication of #2 so I don't see why it would be a problem with the HPCR.