My truck mods are similar to yours, see my sig. I have a 7 PSI Carter pusher mounted back by the tank. So far, I have only done mild fuel line upgrades, changing out the banjos for Weber style fittings and -AN6 stainless steel braided lines from just before the OEM lift pump through the fuel filter up to the VP44. I run ~18 PSI at idle, 13 - 15 PSI at cruise and at WOT with the drag Comp on kill, I pull it down to ~10 PSI. I am still using the OEM pickup system into the tank.
When I finally get around to it, I would like to tap into the side of my TransferFlow tank about 1 - 2" up from the bottom, and use a bulkhead fitting and then run -AN8 or -AN10 lines from the tank to a completely aftermarket pump (I was looking seriously at the PR 4200 series... ) and then an aftermarket filtration setup, then into the VP44.
Tom