Absolutely... . air in/air out... . a good start. .
A well tuned and timed injection pump
A set of larger injectors (with in reason for mileage purposes)
Alot more attention to using gears/RPM properly
Hybrid/modified turbo charger... . smaller exhaust housings really do basically one thing well, they improve spool times. The do other things poorly, such as high drive pressures, higher EGT's at the mid/top end, can be overspooled and other things as well
The compressor end can be a real help if the hybrid is configured properly. Look at some of the big HP guys who run singles for evidence of that.
You need the turbo combo that will supply as much boost as needed (only), at a preferred temperature. If you run the turbo outside it's map range you get boost at blast furnace temps.
I believe that Dodge went to a lock-up TC system for a couple reasons... one, the 1st gen transmission's (auto's) all run hotter than the 2nd gens... . and that is one reason why DC went to the lock-up system... HEAT. Second they, like other makers, were in a HP race to some extent and they knew that it would require other methods of power transfer to hold on to that extra HP.
Proof??... look at how our 727/A518 would handle 300 RWHP and for how long. With even some modest mods, we can drive the A518 into the 270*F range, that's why there is a temp sensor to lockout OD at that range on a stock truck.
When in lock-up, torque mulitiplication is not in the equation, it's lock-up. If I'd had the extra $$$ I would have gone lock-up though, no question.
Lets be honest, speaking personally here, but if we want hotrod performance we run the ragged edge and pray to the Acceleration Gods that it holds. If I/we want to strike a balance between hotrod and daily, working HP we may go easy on some of the things we do to these great 'ole gals.
There are some mods that can be made to really improve the performance and still be configured correctly to max out daily mileage and still provide riceburner stomping power/smoke when needed.
I personally took one of nascar's mods, and in conjuction with another one of my own, made a nice improvement in my mileage.
On my last dyno run I had some nasty temps and 284 RWHP. That run did not include some mods that you wouldn't normally run as a daily driver so I left them out. BUT at that time my RWHP had gone from 225 RWHP I think it was, to 284. I actually improved my mileage from about 16. 8'ish to a full 18 mpg as it sits now.
Well that's it. No flames intended here guys, just some time spent behind the wrenches, under the hood and listening to the real guru's who have been there and actually done that. .
Bob.