My cruising boost levels should be at 4-5 psi not 8-10 psi. Also when I downshift my boost goes up. Joe Donnelly has said that boost is restriction to flow. I definitely have restriction to flow even at low rpms.
While boost in a sense is resistance to flow, that does not mean it's a bad thing.
What is the reason for a turbocharger in the first place? Obviously, it is to boost the engine's efficiency (no pun intended

) by extracting thermal energy from the exhaust that would otherwise be wasted. Thus, the more of this energy that can be "captured", the more efficient the engine is running.
Say your cruising boost levels are the aforementioned 8 - 10 psi, and then you change to a larger turbo and can cruise at just 4 - 5 psi boost. Does this mean you're running more efficiently? No! No restriction to flow has been altered, other than the turbo. This simply means that the larger turbo is not as effective at harnessing the available exhaust energy and turning it into useable work.
If lower cruising boost meant more efficiency, a normally aspirated engine would be the ticket because there would be no restriction imposed by the turbocharger! Boost is a good thing, and can only be used as a measure of engine load when talking about the exact same charger. Therefore, it's not accurate to install a larger turbo and think the load on the engine is so much less because the boost is lower.
Rather, it takes a certain amount of power to move the truck down the road regardless of what turbo is on the truck. Higher boost numbers would indicate that more available energy from the exhaust is being utilized... and less boost with a larger turbo simply means you are operating way under the turbo's efficiency range, and much of the available exhaust energy is being bypassed due to the large exhaust housing.
If you want to lower cruising boost, the more efficient way to do this is to reduce restriction to flow in the intercooler, piping, intake manifold, exhaust manifold, head, etc. This way, you are still utilizing as much of the exhaust flow as possible with the tighter housing.
This in effect is one reason for most newer vehicles employing variable geometry turbos... so much more energy can be extracted at low power levels, and yet still be able to cool well on the top end.
There's plenty of good information around on people who have done mileage comparisons regarding multiple turbo changes... and almost exclusively, the larger turbos hurt mileage.
--Eric