Yeah, every time the price of fuel goes up the fuel savers make a resurgence. Ain't capitalism and the internet wonderful.
The theory is sound and the silly little things actually work, on a 2500 cc engine. I can just about guarantee that anybody with a testimonial is driving a Honda Civic or a VW TDI, or flat out lying.
The flow rates the little cannisters generate have almost no effect on an engine of any displacement. You would be much better off investing in a water/meth system than one these wonder gadgets for a Cummins sized application.
A couple of other things they don't tell you is they can be extremely detrimental to engine life and electrical systems, especially on computerized vehicles.
The only way to break water down into its components, short of 4500 degrees at 150 psi, is crack it with electricity. These things draw lots of AMPS to do their job. Just imagine a 30 or 40 amp constant load on an alternator.

You think we have problems with light switches and trailer light loads now, imagine THAT on our electrical systems.
The other problem with hydrogen and oxygen these things generate is it burns HOT! Its just about like introducing propane into a diesel engine but with a lot more BTU's. On a mechanical engine the problems are reduced as the computer is not trying to compensate for the added heat with more fuel, but, there is still the issue of regulating so it does not create too MUCH heat.
There is no silver bullet for efficiency, no matter how hard the hawkers guarantee they can suspend the laws physics. Its a zero sum game all around. :-laf
Thats my . 02