I remember doing a design problem in one of my college courses about this. IIRC we had to figure the life cycle of the bearing with the load centered on it and then move it out something like 2 or 3 inches. It cut the life of the bearing by about 2/3, from 1 million cycles to around 350,000 cycles. Then the professor says "just remember this when you drive by those cars that have the wheels sticking way out".
I agree with Hoefler, I would find a single wheel to run if you wanted to do it that way. Or you could take off either one, inner or outer, run for one or two tanks of fuel and then decide if the fuel savings is really that much. I'm thinking it probably wouldn't be worth it but I don't know.
Jeff