Have a Plan FIRST!
Lance,
You dont mention here if you already have a truck or engine lying around, so before you do or buy anything, the best advice I can give is to make a plan. Begin by asking yourself some questions about the finished product, such as "What will I use this truck for?", "Is this truck more tool or toy?", and the all-important "How much do I want to spend?". After you have worked out some ideas about purpose and prices, you may already have answered the "better" and "easier" questions. "Better" really depends on the trucks purpose, and "Easier" is a silly question because it usually depends on your level of ability, and is RARELY easy at all.
That being said, here is my take on the subject, based on my own ongoing project. I already have a solid axle '85 GMC gasser, and its a 3500 Crew. The natural choice for me was a 6BTA conversion. I know my own level of ability: this conversion will be a good blend of things I know and dont know, and I dont have a HUGE fear of the unknown.
If your end result will be mostly street driven or a tow rig, I might lean towards an IFS truck. IFS is known for giving a smoother ride quality. If your end result will be used more off-road, consider that a solid axle truck could be built somewhat lighter, is less complex, and IMHO a lot stronger (but I am a bit biased

).
Kits are available for converting IFS Chevys to solid axle, but that adds to the complexity and cost. Back to the original questions.
Swapping bodies between generations of trucks is possible, but depends on your ability to do the work or your ability to find and pay someone else to do the work. Back to the original questions.
I would recommend that you use a 1-ton truck no matter what you decide, since you are using a very HEAVY and POWERFUL engine. Having a strong foundation is definately a good place to start.
After that, it really comes down to preference in styles. I have always had a soft spot for the '73-'91 GM Square body style.
Also, the rule of conversions says something about the cost and timeframe always being twice what you think it is before you begin - this is ALWAYS true :-laf . Despite what I see on OVERHAULIN', I dont think even Chip Foose could pull this off in a week

.
Again, all of this is just my opinion. Hope it helps!
George