John makes a good point in regards to it being truck components when you jump into that category of motor home.
But I would not be afraid as I am used to this stuff. As with anything you must ask yourself if you can handle some repairs on your own. Most shops have a different labor rate for these as it is harder to get to anything on the engine.
I would have these items at the top of my shopping list....
(1) No CATS. Cummins only.
(2) Air Brakes. Would not give a second look at one equipped with hydraulic brakes.
(3) Can the radiator and / or the charge air cooler be removed easily? If you start looking you will see many equipped with a one piece rear end cap. You can't get the radiator out easily, if at all.The better ones have a two piece rear end cap so the lower half can be removed.
(4) Fan drive. How does it work? If you see that the cooling fan is hydraulic drive walk away. Extremely expensive to fix and usually drive from a pto / pump unit mounted on TOP of the Allison. Not a good time for owner or technician.
(5) Does the bed flip up to allow access to the engine from topside. Do the slides have to be put out to get the bed flipped up?
(6) Tire. I would be looking for 22.5 low profile. The cheapest to buy. 19.5 are not too bad either, but usually see that size on the smaller motor homes.
(7) Check the batteries and cables, look close as there may be a second set elsewhere. Any green goo, crud on the batteries, evidence of several electrical repair attempts? Walk away.
(8) Look for a diesel genset in the nose. If equipped can it be slid out for easier service? Many have this feature.
Just a few thoughts from some the worst that we have had in the shop.....
Mike.