Well these threads are so full of opinions and information! I think both are valuable and worth your time reading them all! I just recently bought a 2017 Mega-Cab, DRW, AISIN WITH 3.73's 4x4 Laramie Longhorn...have a little over 6,000 miles on mostly pulling our 39 ft., 15,000 lbs 5 the wheel from Phoenix to Houston to Tulsa to Colorado Springs and then to here...Rocklin, CA.. I initially looked for a truck with the 4.10's as we have sold our house and are planning on "full-timing" for the next several years and wanted a "towing beast"!... but was going to have to order my truck if I wanted the 4.10's.....so I bought the 3.73'swith a little trepidation! As it turns out, I am very happy with my "compromise"! As others have stated, it really depends on how you drive. When I am pulling I drive at 65-68 mph and my rpms are about 1750-1800...perfect? If I am in city traffic I paddle shift down to 5th and at 60 mph I'm around 1850-1900 rpms....perfect? When I am not towing, I drive around 65-70 mph...not much different as I am not in that big of a hurry! If I spent my towing time at 55-60 mph, then I think the 4.10's would be my choice...and if I cruised at 75-80 I would look at the 3.42's! So unless your trailer demanded the 4.10's...you can pick the gears that fit your driving style! Options! One other opinion to throw out there....I have been pulling stock trailers, travel trailers since the early '80's with half tons, 3/4 tons and my last '07 Dodge was a one ton....all SRW. Now that I am full-timing and not just occasionally pulling....actually "living" in this truck and trailer EVERYDAY...I went with a DRW....what a difference and improvement!!! Hard to believe the difference! I would highly recommend a DRW if you are pulling that 5th more than just occasionally! Good luck with your search...you're gonna love that truck no matter what your final choice!