My thoughts on the question are not worth much, it's a matter of what you like. I don't think the cost, which will be considerable, could ever be recovered by added fuel mileage. The difference in fuel mileage between a Ram with 3. 54/3. 73/4. 10 gears is small.
If you want larger tires for appearance I'd suggest keeping it within reason. Spacers between wheels will leave you with lug bolts that are too short and posslbly outside rear tires that extend beyoned the fenders and sling mud or stones on your truck or following motorists. Could get you tickets in some jurisdictions.