Yes - they sell a flush to clear out the old stuff, for those without an easy way to drain the block completely (i. e. Cummins, as I recall).
I can't do it justice here, but would highly recommend reading their website thoroughly - once you understand how it works, especially compared to water-based coolants and particularly as it reaches the coolants boiling temp, you'll understand it's value.
You'll have other problems before the coolant is an issue - oil too hot, or transmission oil too hot, etc. .
Nice side effect is the ability to run zero (or near zero) pressure in the system too (safer, easier on the radiator, hoses, etc). Now, finding a low-PSI cap can be fun...
If you feel you're likely to run near the limits of cooling capacity, it's a great product.
Mark
I have some friends that run it and swear by it. You just have to make sure the cooling system is totally clean of the normal antifreeze before running it.