I didn't do anything "special" when I changed from conventional to synthetic lube in either differential, but I'm also not an expert mechanic, so I may not be aware of every little detail and best known method. Here is what did:
* Have drain bucket or whatever ready to catch old lube.
* Have putty knife, flat tip screw driver or other tool ready to pry the diff covers off.
* Have socket/open end wrench ready (I forget the correct size).
* Have new lube ready to go
* Have proper gasket material ready to go. I use Permatex High Temp Black RTV (number 598B I think). NOTE: If you are going to use a Mag-HyTec cover, they use a rubber O-ring and do not need or use any sealant.
* Have [new] diff cover ready to go if you are going with a different cover.
* Place catch bucket/pan under diff.
* Remove bottom 2 - 3 bolts, loosen all other diff cover bolts.
* Use putty knife to slowly pry diff cover off, lube will drain out so be ready/careful.
* Let lube drain, then remove diff cover completely.
* Use putty knife, rag, whatever to make certain [new] diff cover is 100% clean and free from any old sealant.
* Some people suggest alternately jacking up each rear wheel to get all possible fluid to drain out of the axle tubes. I didn't do this... maybe should have...
* Use a clean rag to wipe out as much lube that pools in the bottom of the diff housing as you can, etc.
* On diff cover, make sure any drain or temp probe plugs are securely sealed so they won't leak.
* If using a diff cover that uses sealant, run a 1/8" bead of sealant around diff cover, and fully around all bolt holes.
* Place diff cover in position, bolt it in place.
* If you used a diff cover that uses sealant, it is best to wait several hours, 24 if possible, before filling diff with new lube, to allow maximum suring time for the RTV/sealant.
* If using a diff cover that has a temp probe, and you are going to install a temp probe, do so now.
* At appropriate time, fill diff with new lube.
* Again, some have suggested jacking up each rear wheel to get new lube into axle tubes. I have not done this either.
* Of course, check for any leaks. Do this again after say a full day of driving the truck.
I have MagView covers on both ends. They are similar to the Mag HyTec covers, but have lexan windows in them so you can actually see your fluid level. Also, they do not have a dipstick as the Mag HyTec covers do. They also use sealant instead of a rubber O-ring to make the seal. I've had mine on for about 2 years, no problems with them so far.
I'm sure other, more knowledgable folks will add any other tips I missed, or correct any mistakes I may have listed here.
Tom