Tire manufactuers have been telling us that tires on trailers should be replaced after five years of service regardless of tread condition. I'M A BELIEVER! Oo. A recent trip escorting some fire fighters riding bicycles cross country had me suffering three blowouts within a few hundred miles of each other.
I had inflated all five tires on the Alfa to the 80# maximum and the treads were over 60%. Within 100 miles, I had a blowout which required purchase of a new LT 245 75R 16 LR E. A few hundred miles later, another blew and soon after, the spare that replaced it went. :{ I ended up buying four more new tires in Tucson. The fellow at Discount Tires assured me that the 6 year old tires I had been riding on had indeed lived out their expected life.
Bottom line... ... Believe it... tires should be replaced after five years for any highway travels.

Bottom line... ... Believe it... tires should be replaced after five years for any highway travels.
