I didn't have any major problems installing my injectors. Last time was my first and hopefully when my EDM's come it'll take less time, and since I'll be moving my 275's to my buddy's truck, I'll be up to 3 installs. In my mental preparation, the first thing I will try to do is get all the exact size wrenches and sockets set aside beforehand. My biggest hassle was having to get down off the truck, get another size, try it, go back to the toolbox, etc. As far as the #5/#6 cylinders go, I didn't use any different tools. I didn't have a stubby wrench, but was able to use my standard craftsman tools, although it was a royal PITA. The part I was most unsure about the first time was popping the old injectors out, but once I figured out how to pry them out with a bolt threaded in the top, it was pretty easy. Actually, I'd say the most annoying part was probably the blue injector line holders... seemed like I kept dropping things and have to go lookin on the frame rail or ground to find them. I think it took me about 3 hours the first time just because I was being overly cautious. Hopefully it won't take more than 1. 5 hour or so this time around. If you run into a qusetionable situation and don't know what to do, there's a lot of people on here that are willing to help ya out! Just remember, go slow, take your time to do it right, and you shouldn't have any serious problems.