It depends on where they are leaking but as a rule replace the the complete unit and tips. Wear gets to both of them and causes issues.
From all accounts, if you want better mileage a 50 HP tip is a good investment across the board. It varies by truck but generally better idle, better efficency, and more power for a minimal investment.
Wicked Diesel has some of the best prices on stock injectors I have found, they also have better nozzles.
DDP has an excellent results with their nozzles and will uses the same new injectors as the rest.
F1 Diesel has new tips that are top notch and you can get new from them also.
Industrial Injection also has injectors and various nozzle configurations.
I know a couple other independent sources that will offer good deals. PM me if interested.