I went on the quest for better mileage and just from what I've seen in this rig, after running about 6 different sets of injectors total (including stock) in about 158k miles of averaging the numbers, have seen about 1. 25 mpg average difference between all of them (more like 1 max). Now running RV275's and getting about 18. 5 combined hwy/city. That is as high as it has ever done with the exception of mach 1. 0's which were about the same. It's a 4x4. Almost always gets 12-12. 5 on trips towing a 28' fifth wheel.
I would say, choose your injectors according to how much power/egt's you want and your preferred way of getting it (combo of inj's, boxes, etc) and let the mileage fall where it may because it basically comes down to. . If you see smoke, you just wasted fuel. Also, if you're a lead foot, the bigger inj's will allow you to waste fuel quicker. If you're a conservative driver, there won't be as much difference between injectors. JMO