Slowing down is one way to improve fuel consumption but...
When I'm pulling 14K, I find the motor really likes 2,200 RPM. With a gooseneck, I don't seem to have the brick wall you are talking about and putting the rig in the "sweet spot" makes the grades much easier with very little downshifting.
I drive 4,000 miles round trip and almost always go 3-4 MPH over the speed limit. The rig is extremely stable and I obviously slow down for less than perfect conditions.
I'm an old fart too, but 3 MPH over 60 hours of towing gets me to my daily stops 30 minutes quicker and shortens the total round trip considerably. I've also learned that the last 30 minutes of a long day is the worst.
Also, I'm much more in the flow of the traffic, not passing too many people and only getting passed about ½ as much.
Out west where speed limits are 75 MPH, plus my 3 MPH results in 78 MPH and a really nice 2,200+ RPM. With the EZ, downshifts are only on the steepest grades around Flagstaff on I-40. Only when I need to downshift do I have to watch the EGT like a hawk. All the other times the needle will just touch 1,200° while on cruise control.
Having a trailer with 3 axles and 6 brakes helps some, but at the higher speeds, I am VERY careful to be looking ahead and I will quickly click off the cruise control at the slightest indication of a need to slow down.
Just because I grow old does not mean I have to grow up!

Screw the fuel cost...