Your gauges will unlock the door the the highest mpg that YOUR truck is capable of. Remember, the mpg varies quite a bit from one truck to another.
It's not so much ENGINE rpm that determines mpg. Otherwise, you would get the same mpg at 2K rpm in 1st as you do in OD-- and we all know that's not true.
Now engine rpm DOES play a role in overall efficiency, since there are certain rpm ranges where the engine is most efficient.
Monitoring your pyro and your boost gauge will give you a good idea of how hard the engine is working. The lower you can keep these readings while on the hwy, the higher your mileage will be.
This is especially true of the pyro, since it shows you about how much fuel you are burning. Once the boost comes in, it's not so accurate-- but the trend is still observable and the rule of thumb still holds.
Generally, max fuel economy will come in the highest gear at the lowest load, and at the lowest rpm where you can still burn the fuel efficiently.
If you want to prove this to yourself, rent a dyno for a few hours. You will find that if you go about 50mph in OD with little or no load, then our trucks can approach the HIGH 20's for mpg-- 26, 27, even 28 mpg!!
The reality is that you will always have MUCH more load on the engine than under these circumstances, so mpg suffers. The amount of hp required to overcome aerodynamic drag increases DRASTICALLY once you get over 50 mph or so. Do the math and you will see that doubling speed requires FOUR times more power to overcome aero drag.
So the mpg tapers off in OD after a certain rpm (2200 some have reported) not so much because the engine is less efficient at that rpm, but INSTEAD it's because you are traveling faster and placing more load on the engine. Thus, it has to make more power and burn more fuel.
Justin