Brett, if leaving from Buffalo area, why not stay along northern NY and go thru Lake Placid area, former site of the '80 Winter Olympics. Then go across Lake Champlain to the Burlington area, either by ferry or go north and come back down thru the Islands on US 2. Burlington is a nice college town with plenty of things to do. Shelburne Museum is a great place to visit just south of Burlington. Stowe, home of the Trapp Family Lodge, and Newport are nice places to visit or drive through. Any portion of VT rte 100 would be a good ride. Further south US 302 goes from Montpelier toward St Johnsbury area. Another good scenic route. Also, US 302 across NH would be a great trip. It goes near the Mt Washington Road to the Peak. Very interesting climb!!
If wanting to go further south, go to Port Henry, NY and take a free ferry ride across Lake Champlain to Chimney Point then over to Bridport, go south on VT 22A then follow US 4 across the state. This will go thru Rutland, Killington area and thru Woodstock. Again any portion of VT 100 would be great scenery.
There are so many scenic routes to follow here, I won't make this note any longer. Even the Interstates here are very scenic. But if you want any more info just let me know.