jon. other than having the handi cap of higher rpms at highway speeds,i wouldnt worry about the durability of the 4spd holding up behind a[ stock 6bt]. i have the same setup that you are describeing,but my 6. 2 has a banks turbo on it. the entire drivetrain has over 375k on it,10k on the new engine. those were some very hard working miles,with a lot of abuse. i know of many 4spd trannys in 1 tons with modded 454 engines,they are holding very well. round my parts,its a very common transmission to use in 4wd mud trucks,some of these boys run some very high power 454 [expensive] engines. lastly,there is also a local heavy equipment mechanic i have used over the years,he has a 83 model chevy service truck with a 4spd and 3. 42 gears,he has been running a 6bt in it since the late 80's,no probs. a 4500 transmission would be a more pratical choice.