I just started logging the computer readout versus the hand-calculated mileage on 9-12-06. Here are the last three tanks, all pulling a 16' 2-axle fully-enclosed trailer weighing 2840 lbs empty:
512 miles, cruise-control at 64 mph, computer = 13. 9, hand-calc = 13. 364.
387 miles, cruise-control at 64 mph, computer = 12. 7, hand-calc = 12. 152
413 miles, cruise-control at 63 mph, computer = 13. 7, hand-calc = 13. 135
That's a fairly consistent error of . 536, . 548 and . 565 mpg, w/an avg of . 550.
Avg computer reading for those three tanks was 13. 433; avg hand-calc mileage was 12. 884 -- using averages the average discrepancy for all three tanks of fuel, between the computer and the hand-calc was . 459 mpg.
So in my case, both the actual and the average discrepancy between the mileage computer and hand-calculations was approximately 1/2 mile-per-gallon, +/- a few hundredths.