I personally would run the Smarty. The only thing that could potentially damage your truck would be your right foot. The positives outweigh the negatives. A mild tune will tweak the timing and fueling enough to give an increase in mileage (as long as you drive the same as you would without it), and the extra power is on tap for those big grades or heavy loads. Plus you have the ability to read and clear codes, and reprogram the abs. I feel it is the best available tuner on the market for the VP trucks because it fuels hard down low which is where you realistically work the engine the most. I just don't have use for a programmer that makes all its horsepower on the top end of the engine, that's not where I need the power.