I did something similar
I have done something real similar to what you are talking about. It wasn't too hard all in all, but there are several gotcha's.
1) The factory radio (CD or Cassette, and even just the AM/FM) has a switched power lead that you can use to turn the amps on or off.
2) If not cutting into the factory wires is important to you then the job gets a little harder but still not too bad. I went to dodge and got a replacement for the plug at the back of the radio so I could get to all the wires right there w/o cutting into the factory wires.
3) if you have the factory Infinity system and intend to add any amp power to the factory door speakers then you are going to have to remove the amps mounted to the backs of the speakers. I would just replace the door speakers though, they aren't that good.
4) the wiring for the rear speakers goes into the front doors to that amp first, so you'll have to deal with that (I can't remember if this is only on the infinity system, or all trucks)
I started out with an alpine 5 ch amp that had speaker level inputs, but I wanted more power to the subs so I got a line level adapter from Crutchfield. My system now consists of the Alpine 5-ch running just the front door speakers, an AudioControl 2XS set at about 60 hz if I remember correctly and an Orion 280gx driving a pair of 6 1/2 Bazooka bass tubes under the rear seat.
I have no idea what the SPL of the system is, but I can hear and feel it at 80mph on the freeway with the windows down.
To me is sounds good. I like deep low frequency bass, this boom boom crap that some of the kids call good sound just sucks. If I had to guess I'd say I can probably get pretty good sound down to about 40hz or so. Enough to make the rearview mirror jump all around, and much more than would be expected from two 6 1/2 inch subs.
I wanted to keep the OEM head unit so that the truck would look stock. It's bad enough that I've got guages hanging all over the place screaming "Please steal me!!!" to any lowlife walking by, I don't need the stereo helping. I don't feel like I need any other features that my stock radio doesn't have and I didn't have to spend any extra money on it, so I kept it and have been happy so far.
I hope I've answered your questions and that this helps. If you need anything else drop me an email and I'll do what I can.
Mike