There is no physical or functional reason you cannot use and EB on the 48RE.
Seamless control is not supported, that is the root of the Dodge refusal to support it. If you have a shift kit to raise the pressures and add a BD pressure Loc you should be fine in normal usage. You will have to add controls to the base EB to make it work a little more seamlessly.
The only other potential problem is some thrust washers may suffer wear with entended use of the EB. Its more a usage scenario problem than anything. If you have had it rebuilt that problem may be gone.