wastegate?
I have to agree with Pthomas. You should be adding more fuel if you're gonna go up to the 16, then there won't be any difference on the bottom end, but what an improvement on the top, plus lower EGTs & more power. I've got the 16 non-wastegated on a Piers HX-35 custom turbo and it is far superior than the stock unit. Spool up is very fast, and EGTs are about 100 degrees lower while towing.
Like you, I drive the truck daily to work, but pull a big rodeo rig all weekend, grossing about 22,000 lbs. At 75 mph on the flats, I'm running about 18 psi boost at 800 degree EGT pre turbo. Before, I would run about the same boost, but 925-950 degrees. It runs free-er. No real mileage increase towing (10 - 10. 5 mpg), but I have noticed an increase on my unloaded highway mileage, which is up to about 20 now, from 19.
At any rate, you need a fueling plate to benefit from the larger housing.