Lots of people here on the TDR have forgotten the phrase that existed even before the acronym BOMB (better off modified baby!) was born. That all important TDR phrase is: "I AM MY OWN WARRANTY STATION. "
That said, I have put over 100,000 miles on all of my past and current dodge 3500s. Each was modified to add at least an extra 100-140 hp, and each was used to mercilessly tow a 23,000 pound trailer all over the western US (read: hot, dry, and mountainous). I have never had any problems with the Cummins engine. I have had clutch and transmission failures, but these are expected, doing what I do. I have never ran an automatic transmission due to the heavy weights, and I always tow in the highest gear possible, and run the speed limit (usually 70-75 mph) in these parts.
You will shorten the life of your Cummins somewhat, but almost nobody keeps their truck more than 200,000 miles.
My first heavily BOMBed dodge (approx 450 hp) is still on the road with over 450,000 miles, and still runs like a champ, and has never had an easy day.
Your experiences may vary. I know guys that can tear up an anvil with a rubber mallet. Curiously, they have hell with their pickups, too...