I've been researching twins to the point where almost every vendor and person who already has twins is sick of me calling and PMing.
I REALLY like a USB on top because of the high pressure ratios it can generate. IIRC, Pius also has a WSB which is still on the map at 58psi!
With twins, I figure your total airflow (lb/hr) comes from the big charger. The PRESSURE that the air is delivered at comes more from the small charger.
I think of it this way: start with a high pressure-ratio small charger (like a USB) that can do over 4:1, then multiply this already-high ratio with your large charger. Thus, an HT3B running at 2:1 give you 8:1 overall. (2*4=8). If you have a larger charger that can efficiently go 3:1, then you are at 12:1 overall, which is plenty for well over 100psi of boost.
This means the large charger has to be big enough to feed the small one at whatever pressure ratio.
Personally, I think an HT3B is too small to match with a USB. I'd go B2, Ht4B/C, or Big Brother.
Even if not perfect, the Ht3b will spool quickly with the USB and give you a lot of air. The high PR of the Pius turbos gives you a lot of options. You can always swap out the 3b for something bigger later.....
The idea is mass quantities of cool air. I think your combo will ROCK!
Let us know how it goes!
Justin