I have not noticed any vibration with or without a load while in 2nd. I do agree with jelag. My '99 had a 5spd. ,4:10 and 16" tires. My '07 has a 6spd. manual ,3:73 and 17" tires. It took my a while to get used to the new shift points, engine RPM ect.
Jim
'99 3500 C&C
'05 2500 SLT QC 4x4
'07 3500 C&C SLT 4x4