I had an '03 QC SB 4x4 with the 48re and HO engine. That was an awesome truck. Klenger hit the high points, I would look for an HO engine just becuase I don't bomb my trucks. The stronger transmission's though (48re and 5600) are definately something I would want. The tag on the valve cover will give you the HP rating, the HO is 305hp, that is the one I would be looking for. The 305hp engine ensures that you get a good transmission. Front ball joints and driveshaft u-joints are about the only issues, nothing major.