My wife puts around 20K miles a year on her ride.
We had a 2000 Honda CRV LX (loaded). It was nice. Only problem we had was the rear diff fluid had to be changed around 20K to stop a noise while turning, but thats part of maintaince on them. One other thing, the Honda with an auto can be towed behind a motorhome.
The Honda was also pretty low on power. In 2001 they stepped up the power somewhat, but its still a 4cyl. We used to get around mid 20's MPG with it. One thing I also recall was road noise, there is no noise insulation in the thing.
Then we bought her a 2002 Ford Excape Limited. Much more power, almost to much

. When I drive it the MPG is around 17, my wife gets around 21 or so but I notice she also has a heavy foot on the back roads. Much quieter inside. More amercian feel. Hell I think it can even tow 3500 lbs. The wife loves the Ford much more then the CRV, but she was happy with it also.
One thing else, Both are Fwd, then AWD when needed. In the Honda you could feel the transission from fwd to 4wd, and it had a pull in the steering wheel from axle torque when spinning the front. With the Ford, you can never feel the 4wd come on, its a seemless transission. Even works in reverse without a problem.
So far around 35K miles with no problems with the ford, but I got a great deal on a Ford 6 year, 100,000 mile ($400) so I guess if it does brake, it will be ok.
One thing I noticed, every other page in the maintaince section of the owners manual is for a diesel excape. Funny, I never saw that option on the showroom floor!