I noticed that after installing the timing box (Van Aaken) the mileage went up about 1 mpg on average.
Then went to DD1 injectors, and seemed to lose that mpg. Now Have DD3's and its about the same, maybe worse, but have been hot-rodding more than normal so its hard to tell.
The timing box seemed to be the best for mileage in my truck (ETC) w/ my driving style.