Guys,
I have both gears mentioned, so I feel as if I can speak to this a little. My 01 6 speed with 3. 73's has always been first choice to pull our 12,000 lb 5er. It pulls it all day with no add on other than a chip and does just fine. There are some grades i "MAY" need to shift down into 5th gear with but not often. It is for me the preferred truck for the 5er. The other truck is a 02 6 speed with 4. 10's. this truck also does a very good job with the 5er but seems a little , how do I say this? Different. It never needs to be down shifted or at least almost never and a real funny thing about this 4. 10 geared truck it has always from the time it was new gotten 3 or 4 miles to the gallon "BETTER" milage than the 3. 73 truck. That is loaded or empty it just does get better milage. but even with that said it just about drives me crazy driving it empty on the highway. it sounds like it is wound so tight it is going to pop, maybe I notice the difference because I have both geared trucks.
Gunny