We just bought a new 4500 w/ Aisen, 4. 44s and 188" wheel base. It runs and pulls great. It does not have heavy duty spring option on front, which I believe improves the ride empty. Only have 1,500 miles on it and have gotten as high as 14 mpg empty and as low as 8. 0 mpg towing 17K lb 5er and seeing about 12. 8 around town. This rig turns tighter than my 02 3500. The Aisen is sweet. I started out towing in tow/haul mode, but went to normal w/ minor grades. transmission was smooth, would downshift to 5th on grades and upshift when topping. Intersting the exhaust brake never engaged on the down grade side. Again, not too much grade. Truck weighs 10,840 lbs.
Hope this helps, Wiredawg