Went from a 98. 5 (with a Banks Stinger) to a 2006 with 50 hp injectors. Both are 2500's, QC, 4X4 automatics. Quality of ride and power is far superior in the 06. By the way, my son got the 98. 5 and commutes, tows a 35' travel trailer and uses it for hunting. It still has the original 47RE (no repairs, only maintenance at 150K+ miles).
What will you give up? 'Cheaper' interior, thinner sheet metal, less quality paint, etc... I really enjoy driving the 2006 much more and never look back.
Good luck.
Wayne