IMHO, 4. 10's are for towing, 3. 55's are for Fuel Mileage when empty.
4. 10's also allow you the option of using over sized tires and still staying within stock Dodge perimeters.
If it is an automatic trany, you will keep the pump pressure up, and the loads lower on the trany, you may get better trany life or clutch life with the 4. 10's.
Stock 4. 10 on a 3500, 2000 RPM = 60 MPH
Stock 3. 55 on a 3500, 2000 RPM = 70 MPH
A stock 2500 has larger tires than a stock 3500 so its speeds are just a little higher.
Stock 4. 10 on a 2500 with 245, 2000 RPM = 62. 5 MPH. with 265, 65 MPH.
Stock 3. 55 on a 2500 with 245, 2000 RPM = 73 MPH. with 265 about 75 MPH.
The meat of your towing power is going to be from about 1800 - 2700 RPM. I do not cruise over 2500 PRM.
My currant truck is a stock auto with 4. 10's and 285/75 tires. Because of the over size tires, my ratio equals 3. 70. I am doing 68MPH at 2000 RPM. I would go to 265 tires for better towing as it towed better with the stock 245.
My new truck will be used for towing most of the time, I want 4. 10's.
If you use your truck empty or little towing you will get better MPG with the 3. 55.
Hope this helps
Bob
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1998. 5, 2500, SLT, Red over Driftwood, 24V, 4X4, Auto, 4. 10, Light Group, Camper Special group, Convenience Group, Travel Group, Trailer Group, Keyless entry, 5 band EQ and 6 disk changer. (ruck is 4-Sale) towing a 35ft. Travel EZE 5er.
It in, due to pick up May 9 or 10, a 2001 3500, SLT+, Green, Tan leather, Duel Power Seats, HO, 6 speed, 4X4, 4. 10, Towing Package, Trailer Tow Mirrors, Camper Package, Sliding rear Window, Jacob’s E-brakes (Dodge), Electric Steps (Dodge), Mud Flaps on all 4s (Dodge). It has every option offered by dodge except the snowplow, including the front Air Dam. Line-X over the rail bed liner, 20K Reese 5th wheel Hitch with Gooseneck, 30” toolbox.