Pulling a steep grade, sustained high speed, or getting a load going is the only time you'll have EGT problems.
Your right foot is the ultimate temp control.
Your truck will burn the same amount of fuel at a given speed and x RPM with any injector in it.
I'm running a #4 and 370's on a stock turbo

(albeit a 160 pump for now

).
Yes, I CAN bury the temp gauge at will, but don't have to. The truck moves pretty good at 1/2 throttle.
And when I want to stomp a mustang or something, I'll let it get warm for a short run. Cools right back off.
But there is a 215 and bigger spool around the corner.
300's don't give that much improvement. I heard that from a fellow with extensive dyno testing. Get 370's and be done with it.