I been running Nokian Hakkapeliitta LT2 (265/70R17 121/118 Q LT265, Load E) on all six wheels for the past six years. They are sipped, studded and have great snow traction due to the rubber compound. Studs help a lot in the transistion zone driving from rain to black ice to snow. In 4WD, with nothing in the back, it readily handled 9" of sierra cement when Cal-trans would lose control of Hwy 4 during a storm. When the 4,200 lbs truck camper was in the back for winter road trips to ski areas I was never at a loss for traction, even in 2WD mode. The softer rubber compound doesn't have a real long tread lifetime, but I would rather have the traction and buy tires more often, than drift sideways with the camper on and then suddenly have the tires hook up.
I have v-bar chains for all four corners (cross bar reinforced, heavy duty, with cam lock tensioners). The rear chains are now dual/triple chains. Originally I just had single chains. However in very deep, wet snow > 16", found in unplowed Sno-parks after a weekend storm, if you only have a single chain on the outer dual, the inner dual would compact the snow and float both tires and then just spin. Easier to stay in a ski area parking lot that is plowed more often. Up in Montana now and in south eastern BC haven't need the chains.
Truck handles the slush well as it is heavy, but still better to throttle it back some.