I wouldn't bet on similar numbers, MPG-wise. My 2500 has G56x3. 73s and I'm not seeing better than 17 unloaded on the Interstate. Based on a 1/2 MPG increase from taller tires (from stock 31. 6 to 33 inch), I expect to see similar results (in type, not qty, I hope) from going to 3. 42s. With the G56, the 1st gear is low enough that going to 3. 42s shouldn't cause any issues for hauling. You do, however, have to change out the front differential housing.
Got this from
Swapping from 3. 73 to 3. 42 Gears - Page 4
To convert Chrysler (Dodge Ram) to 3. 42 ratio:
Rear
11. 5" Gear Set - 40045439 (New) - (Fits both GM and Chrysler 11. 5 Rears)
Front - A Diff Case and Diff Kit change is necessary for 2003 to 2006 models - use the following parts...
9. 25" Gear Set (New) - 40045288 - (used in 2007 and up)
9. 25" Diff Case (New) - 40028204 - (used in 2007 and up)
9. 25" Diff Kit (New) - 74042462 - (used in 2007 and up)