Adjustments to the doors are to compensate for the compression of the door seals (in most cases) which is normal. What I use to rid myself of the problem... hands down: Honda Shin-Etsu Grease. The best stuff on the market with no adjustments to the doors. I also have a 2005 Honda Odyssey with a big air noise problem. Per Honda I conditioned the seals and the air leaks were gone figured I'd try it on my 06 Mega and it worked too. Don't forget the moon roof! It's the shiz-nitz!
DISCLAIMER: my statement assumes no problems with door alignment, hinges, abuse due to PO'd driver!
Tony