From the owners manual. . (I swear no one reads these things!)
The problem you run into is that Bio is a very aggressive cleaner. If you have never run it, or not for a long time, it can (will) clog your fuel filter.
This is only if your tank is very dirty. The few times I have ran B20 has not effected my filter life at all.
From what I have been reading is that biodiesel has a tendency to wash through the cylinders easier and can contribute to more fuel in oil dilution. That is one reason GM went to the 9th injector and make their new diesels B10 compiiant. Probably why Cummins recommends no more than B5 due to the regenerations and dumping fuel back into the cylinders. The older diesels like my 97 would run on anything without worry.
If you run Bio at all, it will clean as it goes and filter maintenance is within norms. I drive for a company that has a fleet of about 70 trucks and when they switched to B20, filters were clogging in short order. I assure you, we don't drive in dusty conditions (PacNWest) and we aren't in the habit of adding dirt to the tank when we fill up. :-laf Diesel fuel happens to leave small deposits over time, and when the Bio enters the system it scrubs the hell out of it and everything gets trapped in the filter. What happened is that we had never run Bio before, and it clogged the filters.