Drew,
Based on your mods, I think you are low on boost. I am running an Edge EZ with 275's and can pull 30#. This is with an 01, HO. I live at 5600 feet, and drive between 1500 and 8000 with very little difference. I have not seen much difference with high altitude changing max boost. However the lower elivation will spool the turbo quicker. There is a small difference in boost between a hot & dry day vs. a cool & humid day. The cool air will burn the fuel better and produce a little more boost. What are you running for EGT's? With low boost you might be on the hot side. With my mild mods and 30# of boost I just about never have to back out of it. Back to why the low boost on your truck, I am not sure, some others on here will probably know.
"IF IT AIN'T CUMMINS POWERED, IT AIN'T A TRUCK"
"NICK"